Incoming NYU freshmen and childhood neighbors Naomi and Ely have been in love with each other their whole lives, even though Ely isn't exactly into girls. The institution of a "No Kiss List" has prevented the two from rifts in the past, but their bond is tested when they both fall for the same guy. The once-inseparable pair must figure out if their friendship is strong enough to get past such an epic predicament as they struggle with the realities of growing up.

Troy and the gang of East High School are going through their senior year, facing graduating and going their separate ways. Coming to terms with the reality of it all, Troy wants to attend the nearby University of Albuquerque next year on a basketball scholarship, but Gabriella wants to attend Stanford University in California. Meanwhile, Sharpay, the school's shallow and spoiled rich girl, plots to go all out planning the school's final musical show with the idea to add music to her hopes and fears about the future. While Sharpay takes an up-and-coming British exchange student under her wing, her flamboyant fraternal twin brother, Ryan, has his sights set on something different after school. In addition, Troy's best friend and basketball teammate Chad, and Garbiella's best friend Taylor, all have their sights set on their plans after high school and come to terms with the reality of the real world.